Saffron has potent neuroprotective properties protecting function and structure of retinal cells and photoreceptors, protecting agains macular degeneration

Saffron by virtue of its antioxidative and gene-modulating constituents, particularly crocin promotes mRNA expression of gamma-glutamylcysteinyl synthase (gamma-GCS) in PC12 cells, and could be potentially useful in managing diabetic neuropathy. PC12 cell line is a suitable in vitro model of diabetic neuropathy.

Saffron carotenoids have antioxidant activity and therefore can neutralize reactive oxygen species that are involved in pathology of many diseases such as age-related macular degeneration, diabetic retinopathy and renal ischemia-reperfusion (IR)-induced oxidative injury to kidneys.

Saffron 2020 is formulated with 20 mg high quality saffron and is approved in Canada for macular degeneration and cataracts.


References on saffron for macular degeneration:

– Biochim Biophys Act. (2007), 1770: 578-84.

– Cell Mol Neurobiol. (2010), 30:185-91.

– J Pharm Pharm Sci. (2005), 22; 8:387-93.

– Crit Rev Food Sci Nutr. (2004), 44:155-72.

–  Phytother Res. (2000), 14(3):149-52.