Beta-caroten converts to metabolies (called apocaortenoids) that can exert anti-vitamin A activity and disrupt the function of vitamin A in our body (1).

It has been also observed that under high dietary beta-carotene intake, and the oxidative strees of smoking, there was a clear increase in preneoplastic lung cancer lesions in animals (2).

In a human study, subjects supplemented with beta-carotene showed higher incidence of lung cancer (3).




1 – Eroglu A., et al, 2012. Naturally-occurring eccentric cleavage products of provitamin A ?-carotene function as antagonists of retinoic acid receptors.

2- Liu, C. et al. (2000) Carcinogenesis 21, 2245-2253

3- Russell, R. M. (2004) J. Nutr. 134, 262S-268S.